Stem Cells

A multicenter trial looking at whether a single dose of millions of adult, bone-marrow-derived stem cells can aid stroke recovery indicates it's safe and well-tolerated by patients but may not significantly improve their recovery within the first three months, researchers report. However, the trial does provide evidence that giving the therapy early -- within the first 36 hours after stroke symptoms surface -- may enhance physical recovery by reducing destructive inflammation as well as the…
Inspired by the encouraging results of stem cell therapy in the treatment of various diseases, the All India Institute of Medical Sciences (AIIMS) here is all set to start a clinical trial to establish the efficacy of the same. “Since 2003, we have been using stem cell therapy in 35 departments at AIIMS, especially in the treatment of diseases pertaining to the cornea, skin and heart, and the results have been promising,” said Prof. (Dr)…
University of Florida Health researchers have successfully transplanted human stem cells in a mouse model, which developed into fully functional neurons. This is being seen as a promising advance in the direction of unlocking new treatments for epilepsy and other neurological disorders. According to Dr Steven N. Roper, a neurosurgeon and professor in the UF College of Medicine department of neurosurgery, the news is particularly encouraging because the human stem cells not only survived after…
Researchers at the Federal University of Rio de Janeiro (UFRJ) in Brazil have used a US Food and Drug Administration (FDA)-approved anti-cancer drug to grow dopamine-producing neurons derived from embryonic stem cells. These cells remained healthy and functional for as long as 15 months after implantation into mice and restored motor function without forming tumours. "Brief exposure to an anti-cancer drug of pluripotent stem cells turned the transplant safer, by eliminating the risk of tumour…
An RNA molecule called Pnky can be manipulated to increase the production of neurons from neural stem cells according to a research team led by neurosurgeon Daniel A. Lim, M.D., Ph.D. at UC San Francisco. The finding could result in medical approaches for dealing more effectively with a range of neuro degenerative diseases including Alzheimer’s and Parkinson’s. It may be of relevance also in the treatment of traumatic brain injury could and cancer. Co-authors Alex…
Is it possible to reverse damage inflicted on cognitive functions by chemotherapy? Sure, say doctors based on studies with neural stem cells. The preclinical research conducted on rodents by scientists at UC Irvine has shown that neural stem cells could indeed reverse a range of cognitive functions ravaged by chemotherapy. The study used a comprehensive platform of behavioral testing in arriving at this conclusion. Rats not treated with stem cells showed significant learning and memory…
Individuals with relapsing-remitting multiple sclerosis have shown encouraging response to a treatment involving the transplantation of a particular form of stem cell. The treatment led to an improvement in their neurological disability, quality of life, and cognitive function. The study involved giving patients an intravenous infusion of their own (autologous) stem cells harvested from their own peripheral blood or bone marrow with the objective of resetting the functioning of their immune systems. This approach is…
Monday, 02 February 2015 10:14

A diamond edged weapon against cancer

By attaching the chemotherapy drug Epirubicin to nanodiamonds it may be possible to effectively destroy chemoresistant cancer stem cells says a study led by the National University of Singapore (NUS). Led by Assistant Professor Edward Chow, Junior Principal Investigator at the Cancer Science Institute of Singapore (CSI Singapore) at NUS, the study shows that repurposing prevalent chemotherapy drugs with the help of nanotechnology is an effective method for defeating cancer stem cells that are chemoresistant.…
Wednesday, 28 January 2015 15:40

Mastering MS with stem cells

It may be possible soon to reverse some of the symptoms of multiple sclerosis using a patients’ own primitive blood cells may be able to reverse some of the effects of multiple sclerosis, a preliminary study published in the Journal of the American Medical Association suggests. “This is certainly a positive development,” said Bruce Bebo, executive vice president of research for the National Multiple Sclerosis Society. In MS the immune system devours the protective sheath…
Wednesday, 28 January 2015 15:38

Could stem cells hunt down Huntington’s?

Many thousands of Indians will die this year of Huntington’s, a deadly, inherited disease that kills its victims within 15 years of diagnosis. So far, Huntington patients had no hope of checking the deadly march of this disease. Now at last there is something to cheer about: under study for the first time is a stem cell-based a therapy that could slow down this killer. Huntington’s causes uncontrollable movements and mental decline and finally death.…
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